Anti-CD2 / LFA-2 Monoclonal Antibody (Clone:MEM-65)-Biotin Conjugated
Figure 1: Surface staining of human peripheral blood with anti-human CD2 (MEM-65) biotin, streptavidin-APC.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
| Subcellular location: | Cell membrane |
| BioGrid: | 107352. 16 interactions. |
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