Anti-CD2 / LFA-2 Monoclonal Antibody (Clone:LT2)

Product code: 30-1346

Clone name : LT2
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD2
Gene ID : 914
Uniprot ID : P06729
Alternative Name : T-cell surface antigen CD2, Erythrocyte receptor, T-cell surface antigen T11/Leu-5
Immunogen Information : Normal human blood lymphocytes.

CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

Subcellular location: Cell membrane
BioGrid: 107352. 16 interactions.
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