Anti-CD193 / CCR3 Monoclonal Antibody (Clone:5E8)-PE Conjugated
Figure 1: Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | In eosinophils as well as trace amounts in neutrophils and monocytes. |
| BioGrid: | 107637. 7 interactions. |
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