Anti-CD19 Monoclonal Antibody (Clone:LT19)-Biotin Conjugated
Figure 1: Surface staining of human peripheral blood cells with anti-human CD19 (LT19) biotin.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
| Subcellular location: | Membrane |
| Post transnational modification: | Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. |
| BioGrid: | 107368. 16 interactions. |
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