Anti-CD19 Monoclonal Antibody (Clone:4G7 )-PE/DyLight Conjugated

Figure 1: Flow cytometry analysis (surface staining) of human peripheral blood leukocytes with anti-human CD19 (4G7) PE-DyLight® 594.

Anti-CD19 Monoclonal Antibody (Clone:4G7 )-PE/DyLight Conjugated

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Product code: 30-2476

Clone name :	4G7
Clonality :	Monoclonal
Application :	FACS
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 tests
Isotype :	Mouse IgG1
Purification :	Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-DyLightÂ®594 (PE-DyLightÂ®594) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content :	Formulation: Stabilizing phosphate-buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition :	Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.


Gene :	CD19
Gene ID :	930
Uniprot ID :	P15391
Alternative Name :	CD19, B4, Leu-12, CVID3
Immunogen Information :	Human CCL (chronic lymphocytic leukemia) cells

Specificity: The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19.<Br> CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Membrane
Post transnational modification:	Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
BioGrid:	107368. 16 interactions.