Anti-CD19 Monoclonal Antibody (Clone:4G7 )-PE/DyLight Conjugated

Product code: 30-2476

Clone name : 4G7
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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100 tests
$494.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Purification : Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-DyLight®594 (PE-DyLight®594) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content : Formulation: Stabilizing phosphate-buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD19
Gene ID : 930
Uniprot ID : P15391
Alternative Name : CD19, B4, Leu-12, CVID3
Immunogen Information : Human CCL (chronic lymphocytic leukemia) cells

Specificity: The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19.<Br> CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

 
Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
BioGrid: 107368. 16 interactions.
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