Anti-CD177 Monoclonal Antibody (Clone:MEM-166)

Product code: 30-1199

Clone name : MEM-166
Clonality : Monoclonal
Application : FACS, IP, WB
Reactivity : Non-Human Primates, Human

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0.1 mg
$407.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD177
Gene ID : 57126
Uniprot ID : Q8N6Q3
Alternative Name : CD177, NB1, PRV1, UNQ595/PRO1181
Immunogen Information : Human granulocytes
CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN).

Flow Cytometry Recommended dilution:1 µg/ml
Immunoprecipitation Western Blotting Application note: Non-reducing conditions.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Membrane raft, Secreted, Cytoplasmic granule membrane, Cell projection
Post transnational modification: A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
Tissue Specificity: Highly expressed in normal bone marrow and weakly expressed in fetal liver (PubMed:10753836). During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:24926686). Expressed by a subset of mature neutrophils (at protein level) (PubMed:10753836, PubMed:28240246, PubMed:12377969, PubMed:18462208, PubMed:12675722, PubMed:17244676, PubMed:17580308, PubMed:21193407, PubMed:24926686, PubMed:28807980, PubMed:27227454). The percentage of neutrophils expressing CD177 varies across the population (PubMed:17244676, PubMed:27227454). Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969).
BioGrid: 121389. 3 interactions.
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