Anti-CD169 / Siglec-1 Monoclonal Antibody (Clone:7-239)-APC Conjugated

Product code: 30-1824

Clone name : 7-239
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, Functional Assay
Reactivity : Human
Conjugate : APC

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100 tests
$468.00 

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For estimated delivery dates, please contact us at [email protected]


Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : SIGLEC1
Gene ID : 6614
Uniprot ID : Q9BZZ2
Alternative Name : SIGLEC1, SN
Immunogen Information : human rhinovirus 14-infected monocyte-derived dendritic cells
CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the sialic acid binding Ig-like lectin family. It binds to sialylated glycoproteins on various haematopoietic cells to mediate cell-cell interactions. CD169 is expressed on a subset of macrophages and dendritic cells. On CD14+ monocytes its expression can be induced by interferon alpha and gamma. High expression of CD169 is observed in the spleen, lymph nodes, bone marrow, and under inflammatory conditions rheumatoid arthritis and atherosclerosis, lower in the liver, lungs and gut. It has been shown to be involved in antigen presentation to invariant NKT cells, which play an important role in the innate arm of the immune system to modulate the subsequent acquired immune responses.
Subcellular location: Secreted
Tissue Specificity: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
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