Anti-CD162 (Selectin P Ligand) Monoclonal Antibody(Clone: PSGL1/1567)
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| Amount : | 100 µg |
| Isotype : | Mouse IgM, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Column Chromatography. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml)
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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