Anti-CD162 / PSGL-1 Monoclonal Antibody (Clone:TC2)
Figure 1: Surface staining of human peripheral blood cells with anti-human CD162 (clone TC2).
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Format : | Purified |
Amount : | 0.1 mg |
Isotype : | Mouse IgG1 |
Purification : | Purified by protein-A affinity chromatography |
Storage condition : | Store at 2-8°C. Do not freeze. |
CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.
Flow Cytometry Recommended dilution:1.5 - 2.5 µg/ml
Positive control:human peripheral blood
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Membrane |
Post transnational modification: | Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling. |
Tissue Specificity: | Expressed on neutrophils, monocytes and most lymphocytes. |
BioGrid: | 112304. 6 interactions. |
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