Anti-CD162 / PSGL-1 Monoclonal Antibody (Clone:TB5)(Discontinued)

Product code: 30-1198

Clone name : TB5
Clonality : Monoclonal
Application : FACS, IHC
Reactivity : Human

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : SELPLG
Gene ID : 6404
Uniprot ID : Q14242
Alternative Name : SELPLG
CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.

Flow Cytometry Immunohistochemistry Positive tissue:tonsil, spleen

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
Tissue Specificity: Expressed on neutrophils, monocytes and most lymphocytes.
BioGrid: 112304. 6 interactions.
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