Anti-CD161 Monoclonal Antibody (Clone:10/78)

Product code: 30-1464

Clone name : 10/78
Clonality : Monoclonal
Application : FACS
Reactivity : Rat

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0.1 mg
$363.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Klrb1a
Gene ID : 362443
Uniprot ID : P27471
Alternative Name : Antigen 3.2.3, CD161 antigen-like family member A, Natural killer cell surface protein P1-3.2.3, CD161a, Nkrp1a
Immunogen Information : Splenic cells purified from the LEW rat

CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.

Subcellular location: Membrane
Tissue Specificity: Expressed in a subset of natural killer cells.
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