Anti-CD16 / FcgammaRIII Monoclonal Antibody (Clone:MEM-154)

Product code: 30-1120

Clone name : MEM-154
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : FCGR3A
Gene ID : 2214
Uniprot ID : P08637
Alternative Name : FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Immunogen Information : Human granulocytes

CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms - FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.

Flow Cytometry Recommended dilution: 5-10 µg/ml
Positive control: PBL (peripheral blood lymphocytes)
Application note: The antibody MEM-154 does not react with CD16a present on NK cells in many subjects. Immunoprecipitation Western Blotting Application note: Non-reducing conditions. Functional Application The antibody MEM-154 blocks binding of human IgG to FcgammaRIII.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Secreted
Post transnational modification: The soluble form is produced by a proteolytic cleavage.
Tissue Specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
BioGrid: 108508. 11 interactions.
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