Anti-CD16 / FcgammaRIII Monoclonal Antibody (Clone:MEM-154)-PE Conjugated
Figure 1: Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD16 (MEM-154) PE. The antibody MEM-154 does not react with CD16a present on NK cells in many subjects.
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Amount : | 100 tests |
Isotype : | Mouse IgG1 |
Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms - FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
Subcellular location: | Cell membrane, Secreted |
Post transnational modification: | The soluble form is produced by a proteolytic cleavage. |
Tissue Specificity: | Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. |
BioGrid: | 108508. 11 interactions. |
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