Anti-CD16 / FcgammaRIII Monoclonal Antibody (Clone:3G8)-PE Conjugated

Product code: 30-2300

Clone name : 3G8
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : FCGR3A
Gene ID : 2214
Uniprot ID : P08637
Alternative Name : FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Immunogen Information : Human neutrophils

CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms - FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.

Subcellular location: Cell membrane, Secreted
Post transnational modification: The soluble form is produced by a proteolytic cleavage.
Tissue Specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
BioGrid: 108508. 11 interactions.
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