Anti-CD158f Monoclonal Antibody (Clone:UP-R1)-PE Conjugated

Product code: 30-2387

Clone name : UP-R1
Clonality : Monoclonal
Application : FACS, ICC
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : KIR2DL5A
Gene ID : 57292
Uniprot ID : Q8N109
Alternative Name : CD158f1, CD158F, CD158F1, KIR2DL5
Immunogen Information : Human CD158f-Ig fusion protein
CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population.
Subcellular location: Cell membrane
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