Anti-CD158d / KIR2DL4 Monoclonal Antibody (Clone:mAb#33)
Figure 1: Flow cytometry multicolor surface staining of human lymphocytes using anti-human CD158d (mAb#33) purified antibody and surface anti-human CD56 (LT56) PE antibody
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
Flow Cytometry Recommended dilution:1 µg/ml
Immunoprecipitation Western Blotting Immunocytochemistry Functional Application Cytokine secretion studies
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| BioGrid: | 110006. 5 interactions. |
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