Anti-CD158d / KIR2DL4 Monoclonal Antibody (Clone:mAb#33)-APC Conjugated

Product code: 30-1767

Clone name : mAb#33
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : APC

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : KIR2DL4
Gene ID : 3805
Uniprot ID : Q99706
Alternative Name : KIR2DL4, CD158D, KIR103AS
Immunogen Information : NK3.3 cells and KIR2DL4-Ig fusion protein

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

Subcellular location: Cell membrane
BioGrid: 110006. 5 interactions.
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