Anti-CD158a/g/h Monoclonal Antibody (Clone:HP-MA4)

Product code: 30-1560

Clone name : HP-MA4
Clonality : Monoclonal
Application : FACS, IP
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : KIR2DL1
Gene ID : 3802
Uniprot ID : P43626
Alternative Name : KIR2DL1, CD158A, NKAT1
Immunogen Information : Human NK cell line LB2
Killer cell immunoglobulin-like receptors (KIRs) are polymorphic transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain (such as CD158a / KIR2DL1) transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain (such as CD158g / KIR2DS5, CD158h / KIR2DS1, or KIR2DS3) lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for CD158 isoforms are subsets of MHC class I molecules.
Subcellular location: Cell membrane
Tissue Specificity: Expressed by NK cells.
BioGrid: 110003. 25 interactions.
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