Anti-CD154 / CD40L Monoclonal Antibody (Clone:MR-1)

CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

Flow Cytometry Recommended dilution:4 µg/ml
Positive control:6-8 hour activated mouse splenocytes Immunoprecipitation Immunohistochemistry Immunocytochemistry Functional Application Blocking T cell costimulation in vivo.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	The soluble form derives from the membrane form by proteolytic processing.
Tissue Specificity:	Specifically expressed on activated CD4+ T-lymphocytes.

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