Anti-CD154 / CD40L Monoclonal Antibody (Clone:MR-1)-FITC Conjugated

Product code: 30-2061

Clone name : MR-1
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse
Conjugate : FITC

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0.1 mg
$407.00 

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Amount : 0.1 mg
Isotype : Hamster IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : Cd40lg
Gene ID : 21947
Uniprot ID : P27548
Alternative Name : Cd40lg, Cd40l, Tnfsf5
Immunogen Information : Activated mouse Th1 clone D1.6

CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

Subcellular location: Secreted
Post transnational modification: The soluble form derives from the membrane form by proteolytic processing.
Tissue Specificity: Specifically expressed on activated CD4+ T-lymphocytes.
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