Anti-CD154 / CD40L Monoclonal Antibody (Clone:24-31)-Low Endotoxin

Product code: 30-1663

Clone name : 24-31
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Low Endotoxin
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD40LG
Gene ID : 959
Uniprot ID : P29965
Alternative Name : CD40LG, CD40L, TNFSF5, TRAP
Immunogen Information : human CD154 fusion protein

CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

Flow Cytometry Immunocytochemistry Functional Application blocking

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Secreted
Post transnational modification: Not O-glycosylated.
Tissue Specificity: Specifically expressed on activated CD4+ T-lymphocytes.
BioGrid: 107397. 9 interactions.
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