Anti-CD144 / VE-cadherin Monoclonal Antibody (Clone:55-7H1)

Product code: 30-1556

Clone name : 55-7H1
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, ICC
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CDH5
Gene ID : 1003
Uniprot ID : P33151
Alternative Name : CDH5
Immunogen Information : Human endothelial cells
CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
Subcellular location: Cell junction, Cell membrane
Post transnational modification: O-glycosylated.
Tissue Specificity: Endothelial tissues and brain.
BioGrid: 107438. 94 interactions.
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