Anti-CD140b / PDGF-RB Monoclonal Antibody (Clone:18A2)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
Flow Cytometry Recommended dilution:1-5 µg/ml
Immunocytochemistry
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cytoplasmic vesicle, Lysosome lumen |
| Post transnational modification: | Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation. |
| BioGrid: | 111185. 78 interactions. |
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