Anti-CD140b / PDGF-RB Monoclonal Antibody (Clone:18A2)-APC Conjugated
Figure 1: Anti-Hu CD140b APC antibody (concentration in sample 5 μg/ml, red-filled histogram) binds specifically to CD140b on surface of PFGF-RB transfected 3T3 cells (upper panel), but not to non-transefected 3T3 cells (lower panel). Level of non-specific binding was assessed using Mouse IgG1 isotype control APC antibody (MOPC-21) under same conditions (concentration in sample 5 μg/ml, black-dashed histogram).
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
| Subcellular location: | Cell membrane, Cytoplasmic vesicle, Lysosome lumen |
| Post transnational modification: | Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation. |
| BioGrid: | 111185. 78 interactions. |
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