Anti-CD14 / LPS-receptor Monoclonal Antibody (Clone:MEM-15)-PE/DyLight Conjugated

Product code: 30-2467

Clone name : MEM-15
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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100 tests
$494.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD14
Gene ID : 929
Uniprot ID : P08571
Alternative Name : CD14
Immunogen Information : A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.

CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.

Subcellular location: Cell membrane, Secreted, Membrane raft, Golgi apparatus
Post transnational modification: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Tissue Specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
BioGrid: 107367. 35 interactions.
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