Anti-CD138 / Syndecan 1 Monoclonal Antibody (Clone:MI15)(Discontinued)
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified from hybridoma culture supernatant by protein-A affinity chromatography. |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
| Subcellular location: | Membrane, Secreted, Secreted |
| Post transnational modification: | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. |
| BioGrid: | 112284. 54 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
