Anti-CD138 / Syndecan 1 Monoclonal Antibody (Clone:MI15)-APC Conjugated(Discontinued)

Product code: 30-1825

Clone name : MI15
Clonality : Monoclonal
Application : FACS, IP, WB, IHC
Reactivity : Human, Non-Human Primates, Rat
Conjugate : APC

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : SDC1
Gene ID : 6382
Uniprot ID : P18827
Alternative Name : SDC1, SDC
Immunogen Information : A mixture of U266 and XG-1 human myeloma cell lines
CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
Subcellular location: Membrane, Secreted, Secreted
Post transnational modification: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
BioGrid: 112284. 54 interactions.
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