Anti-CD123 Monoclonal Antibody (Clone:6H6)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
Uetz-von Allmen E, Samson GPB, Purvanov V, Maeda T, Legler DF.
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration.
Front Immunol. 2021 Sep 16;12:702453. doi: 10.3389/fimmu.2021.702453.
PMID: 34603281; PMCID: PMC8482423.
| Subcellular location: | Membrane |
| BioGrid: | 109778. 11 interactions. |
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