Anti-CD123 Monoclonal Antibody (Clone:6H6)

Product code: 30-1502

Clone name : 6H6
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : IL3RA
Gene ID : 3563
Uniprot ID : P26951
Alternative Name : IL3RA, IL3R
Immunogen Information : IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.

Uetz-von Allmen E, Samson GPB, Purvanov V, Maeda T, Legler DF.
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration.
Front Immunol. 2021 Sep 16;12:702453. doi: 10.3389/fimmu.2021.702453.
PMID: 34603281; PMCID: PMC8482423.

Subcellular location: Membrane
BioGrid: 109778. 11 interactions.
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