Anti-CD11b Monoclonal Antibody (Clone:ICRF44)-Biotin Conjugated

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Product code: 30-1909

Clone name :	ICRF44
Clonality :	Monoclonal
Application :	FACS, IP, IHC-Fr, ICC, Functional Assay
Reactivity :	Human, Non-Human Primates
Conjugate :	Biotin

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	0.1 mg
Isotype :	Mouse IgG1
Storage condition :	Store at 2-8°C. Do not freeze.


Gene :	ITGAM
Gene ID :	3684
Uniprot ID :	P11215
Alternative Name :	ITGAM, CD11B, CR3A
Immunogen Information :	Rheumatoid synovial cells and human monocytes.

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Subcellular location:	Cell membrane, Membrane raft
Tissue Specificity:	Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).
BioGrid:	109890. 10 interactions.