Anti-CD11b / Mac-1 alpha Monoclonal NALE(Clone:M1/70)

Product code: 30-1625

Clone name : M1/70
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$345.00 

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Amount : 0.1 mg
Isotype : Rat IgG2b
Purification : Purified by protein-G affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ITGAM
Gene ID : 3684
Uniprot ID : P11215
Alternative Name : ITGAM, CD11B, CR3A
Immunogen Information : B10 mouse spleen cells enriched for T cells

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Flow Cytometry Recommended dilution:1 µg/ml
Immunoprecipitation Immunohistochemistry (frozen sections) Functional Application In vitro blocking of CD11b

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Membrane raft
Tissue Specificity: Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).
BioGrid: 109890. 10 interactions.
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