Anti-CD11b / Mac-1 alpha Monoclonal Antibody (Clone:M1/70)-APC Conjugated
Figure 1: Surface staining of CD11b in murine peritoneal fluid with anti-CD11b (M1/70) APC.
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
| Gene : | Itgam |
| Uniprot ID : | P05555 |
| Alternative Name : | ITGAM, CD11B, CR3A |
| Immunogen Information : | B10 mouse spleen cells enriched for T cells |
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
| Subcellular location: | Cell membrane, Membrane raft |
| Tissue Specificity: | Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a subset of peritoneal mast cells (PubMed:9862668). |
| BioGrid: | 109890. 10 interactions. |
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