Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:MEM-25)

Product code: 30-1116

Clone name : MEM-25
Clonality : Monoclonal
Application : FACS, IP, Functional Assay
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ITGAL
Gene ID : 3683
Uniprot ID : P20701
Alternative Name : ITGAL, CD11A
Immunogen Information : Leukocytes from a pacient suffering from a LGL-type leukaemia.
CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.

Flow Cytometry Recommended dilution:2 µg/ml
Immunoprecipitation excellent antibody for immunoaffinity purification of LFA-1 complex Functional Application The antibody MEM-25 partially blocks binding of LFA-1 complex to ICAM-1.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Tissue Specificity: Leukocytes.
BioGrid: 109889. 6 interactions.
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