Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:M17/4)

Product code: 30-1433

Clone name : M17/4
Clonality : Monoclonal
Application : FACS, IP, IHC-Fr, Functional Assay
Reactivity : Mouse

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0.1 mg
$345.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Rat IgG2a
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Itgal
Gene ID : 16408
Uniprot ID : P24063
Alternative Name : Itgal, Lfa-1, Ly-15
Immunogen Information : C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.

Flow Cytometry Recommended dilution: 1 µg/ml
Immunoprecipitation Immunohistochemistry (frozen sections) Positive tissue:mouse spleen or thymus
Application note:acetone fixation
Functional Application Blocking

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents.
Tissue Specificity: Leukocytes.
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