FITC Conjugated, Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:M17/4)
Figure 1: Surface staining of murine monocytes using anti-CD11a monoclonal antibody (clone M17/4) FITC.
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG2a |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
| Subcellular location: | Cell membrane |
| Post transnational modification: | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. |
| Tissue Specificity: | Leukocytes. |
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