Anti-CD117 antibody(DMC446); IgG1 Chimeric mAb

Product code: 12-9434

Clone name : DMC446
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Available Pack Size(s)

  •   10 µg

  •   100 µg

  • $355.00 

  • $637.00 

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Amount : 100 µg
Isotype : Rabbit/Human Fc chimeric IgG1
Purification : Purified from cell culture supernatant by affinity chromatography
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage condition : Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Uniprot ID : P10721
Alternative Name : C-Kit; CD117; MASTC; PBT; SCFR; KIT
Description :Anti-CD117 antibody(DMC446); IgG1 Chimeric mAb
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains; a transmembrane region; and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand; stem cell factor (SCF); this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation; differentiation; migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis; stem cell maintenance; gametogenesis; melanogenesis; and in mast cell development; migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors; mast cell disease; acute myelogenous leukemia; and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

FACS 1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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