PE Conjugated, Anti-CD114 / G-CSFR Monoclonal Antibody (Clone:LMM741)

Figure 1: Surface staining of CD114 in human peripheral blood with anti-CD114 (LMM741) PE.

PE Conjugated, Anti-CD114 / G-CSFR Monoclonal Antibody (Clone:LMM741)

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Product code: 30-2131

Clone name :	LMM741
Clonality :	Monoclonal
Application :	FACS
Reactivity :	Human
Conjugate :	PE

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 tests
Isotype :	Mouse IgG1
Content :	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition :	Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.


Gene :	CSF3R
Gene ID :	1441
Uniprot ID :	Q99062
Alternative Name :	CSF3R, GCSFR
Immunogen Information :	CHO cells transfected with human CD114

CD114 / G-CSFR (granulocyte colony-stimulating factor receptor, also known as CSF3R) is a type I transmembrane glycoprotein which upon binding of its ligand (G-CSF, granulocyte colony-stimulating factor) homodimerizes and activates signaling transduction to mediate cell proliferation, survival, and differentiation. It is expressed by granulocytes at all stages of their differentiation, as well as by monocytes, dendritic cells, and mature platelets. Among non-hematopoietic cells, it is expressed e.g. by endothelial cells, placenta, trophoblasts, and many tumor cell lines. This antigen is a target for stem cell mobilization for blood stem cell transplantation, for enhancing recovery of myelopoiesis following chemotherapy and in the treatment of patients with severe chronic neutropenia.

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane
Post transnational modification:	N-glycosylated.
Tissue Specificity:	One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.
BioGrid:	107828. 13 interactions.