Anti-CD106 / VCAM-1 Monoclonal Antibody (Clone:STA)

CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.

Flow Cytometry Recommended dilution:4-6 µg/ml
Positive control:TNF-alpha activated HUVEC cells
Immunoprecipitation Immunohistochemistry (frozen sections) Application note:acetone fixation
ELISA Application note: capture mAb for soluble CD106

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Membrane
Post transnational modification:	Sialoglycoprotein.
Tissue Specificity:	Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
BioGrid:	113255. 452 interactions.

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