Biotin Conjugated, Anti-CD106 / VCAM-1 Monoclonal Antibody (Clone:STA)

Product code: 30-1898

Clone name : STA
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : Biotin

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0.1 mg
$433.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store at 2-8°C. Do not freeze.
Gene : VCAM1
Gene ID : 7412
Uniprot ID : P19320
Alternative Name : VCAM1
Immunogen Information : Human DS6 T cell line

CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.

Subcellular location: Membrane
Post transnational modification: Sialoglycoprotein.
Tissue Specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
BioGrid: 113255. 452 interactions.
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