Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)

Product code: 30-1313

Clone name : MEM-229
Clonality : Monoclonal
Application : ICC, IHC, FACS, WB
Reactivity : Pig, Human
Conjugate : Unconjugated

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : Purified by protein-A affinity chromatography
Content : 1mg/ml, Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : ENG
Gene ID : 2022
Uniprot ID : P17813
Alternative Name : ENG, END
Immunogen Information : Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.

CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Flow cytometry: Recommended dilution: 2-6 μg/ml; positive control: Kg1 human acute myelogenous leukemia cell line. 
Immunohistochemistry (frozen sections): Recommended dilution: 1:200, acetone fixation. 
Western blotting: Non-reducing conditions.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Tissue Specificity: Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).
BioGrid: 108337. 12 interactions.
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