PE Conjugated, Anti-CD103 / Integrin alpha E Monoclonal Antibody (Clone:Ber-ACT8)

Product code: 30-2322

Clone name : Ber-ACT8
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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Price
100 tests
$468.00 

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For estimated delivery dates, please contact us at [email protected]


Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : ITGAE
Gene ID : 3682
Uniprot ID : P38570
Alternative Name : ITGAE
Immunogen Information : HTLV-1 induced human T cell line MAPS16

CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.

Subcellular location: Membrane
Tissue Specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
BioGrid: 109888. 3 interactions.
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