Anti-CD101 Monoclonal Antibody (Clone:BB27)
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Format : | Purified |
Amount : | 0.1 mg |
Isotype : | Mouse IgG1 |
Purification : | Purified by protein-A affinity chromatography |
Content : | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Storage condition : | Store at 2-8°C. -20°C for long term storage. |
CD101 is a type I transmembrane glycoprotein, which forms disulfide-linked homodimers. It is expressed on activated T cells, as well as on granulocytes, monocytes, dendritic cells or mucosal T cells. It plays a major role in the activation of T cells by skin dendritic cells. Function of CD101 has not been fully elucidated, but in mice its knock-out results in liver autoimmune disease induced by Novosphingobium aromaticivorans.
Flow cytometry: Recommended dilution: 1-4 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Membrane |
Post transnational modification: | N-glycosylated. |
Tissue Specificity: | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
BioGrid: | 114795. 3 interactions. |
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