Anti-CD10 / CALLA Monoclonal Antibody (Clone:LT10)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by precipitation and chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD10 (neutral endopeptidase - NEP, common acute lymphocytic leukemia antigen - CALLA, membrane metallo-endopeptidase - MME, enkefalinase) is a 100-kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. |
| BioGrid: | 110455. 102 interactions. |
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