Anti-Catenin, beta (CTNNB1) Recombinant Mouse Monoclonal Antibody (Clone:rCTNNB1/2173)

Name: Anti-Catenin, beta (CTNNB1) Recombinant Mouse Monoclonal Antibody (Clone:rCTNNB1/2173)
Brand: Abeomics
SKU: 12-1092
Price: 520.0000 USD
Availability: InStock
Rating: 4.6 (10 reviews)

Figure 1: Formalin-fixed, paraffin-embedded human Breast Cancer stained with Beta-Catenin Mouse Recombinant Monoclonal Antibody (rCTNNB1/2173).

Anti-Catenin, beta (CTNNB1) Recombinant Mouse Monoclonal Antibody (Clone:rCTNNB1/2173)

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Figure 1: Formalin-fixed, paraffin-embedded human Breast Cancer stained with Beta-Catenin Mouse Recombinant Monoclonal Antibody (rCTNNB1/2173).

Figure 2: SDS-PAGE Analysis of Purified Beta-Catenin Mouse Recombinant Monoclonal Ab (rCTNNB1/2173).

Figure 3:Analysis of Protein Array containing >19,000 full-length human proteins usingBeta-Catenin Mouse Monoclonal Antibody (rCTNNB1/2173) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 12-1092

Clone name :	rCTNNB1/2173
Clonality :	Monoclonal
Application :	IF, WB, IHC
Reactivity :	Human, Mouse, Rat

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS / Manual MSDS

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1, kappa
Purification :	Protein A/G
Content :	200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	CTNNB1
Gene ID :	1499
Uniprot ID :	P35222
Alternative Name :	Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1
Immunogen Information :	Recombinant full-length human CCNB1 protein

Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throÂµghout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Immunofluorescence (1-2Âµg/ml); Western Blot (1-2Âµg/ml); ,Immunohistochemistry (Formalin-fixed) (1-2Âµg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Nucleus, Cytoplasm, Cell junction, Cell junction, Cell membrane, Cytoplasm, Cytoplasm, Cell junction, Cytoplasm
Post transnational modification:	Deacetylated at Lys-49 by SIRT1.
Tissue Specificity:	Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).
BioGrid:	107880. 630 interactions.