Anti-c-Myc / Cellular myelocytomatosis oncogene Monoclonal Antibody (Clone:9E10)

Product code: 30-2409

Clone name : 9 E 10
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$525.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : MYC
Gene ID : 4609
Uniprot ID : P01106
Alternative Name : MYC, BHLHE39
Immunogen Information : Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.
Subcellular location: Nucleus, Nucleus
Post transnational modification: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
BioGrid: 110694. 668 interactions.
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