Anti-BCL2L1 antibody(DM189), Rabbit mAb

Product code: 12-9360

Clone name : DM189
Clonality : Monoclonal
Application : ELISA, FACS
Reactivity : Human

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Size
Price
100 µg
$637.00 

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Amount : 100 µg
Purification : Purified from cell culture supernatant by affinity chromatography
Content :
Not Sterile
Storage condition : Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Alternative Name : Bcl-X, BCL-XL/S, BCL2L, BCLX, PPP1R52

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

ELISA 1/5000-10000;FACS 1/100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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