Anti-Bcl-6 (Follicular Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rBCL6/1527)

Figure 1: Formalin-fixed, paraffin-embedded human Hodgkin’s Lymphoma stained with BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527).

Anti-Bcl-6 (Follicular Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rBCL6/1527)

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Figure 1: Formalin-fixed, paraffin-embedded human Hodgkin’s Lymphoma stained with BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527).

Figure 2: SDS-PAGE Analysis of Purified BCL-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527).

Figure 3:Analysis of Protein Array containing more than 19,000 full-length human proteins using Bcl-6 Mouse Recombinant Monoclonal Antibody (rBCL6/1527). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 12-1080

Clone name :	rBCL6/1527
Clonality :	Monoclonal
Reactivity :	Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS / Manual MSDS

Format :	Purified
Amount :	100 µg
Purification :	Protein A/G
Content :	200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	BCL6
Gene ID :	604
Uniprot ID :	P41182
Alternative Name :	B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Immunogen Information :	Recombinant fragment of human bcl-6 protein (around aa 256-389) (exact sequence is proprietary)

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Subcellular location:	Nucleus
Post transnational modification:	Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.
Tissue Specificity:	Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
BioGrid:	107076. 119 interactions.