Anti-BAP1 (BRCA1 Associated Protein 1) Monoclonal Antibody(Clone: BAP1/2667)
Fig. 1: SDS-PAGE Analysis Purified BAP1 Mouse Monoclonal Antibody (BAP1/2667). Confirmation of Purity and Integrity of Antibody.
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Shipping Info:
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| Amount : | 100 µg |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | BAP1 |
| Gene ID : | 8314 |
| Uniprot ID : | Q92560 |
| Alternative Name : | BAP1; BRCA1 associated protein 1; Cerebral protein 13; Cerebral protein 6; HUCEP 13; Hucep 6; HUCEP13; Hucep6; TPDS; Ubiquitin carboxy terminal hydrolase; Ubiquitin carboxyl terminal hydrolase BAP1; UCHL2 |
| Immunogen Information : | Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary) |
The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
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