Anti-AGR3 Monoclonal Antibody (Clone:AGR3.1)
Figure 1: Immunohistochemistry staining of AGR3 with mouse monoclonal AGR3.1 in paraffin-embedded sections of breast carcinoma.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG-3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.
Western Blotting Recommended dilution: 1 µg/ml
Positive control: T47D breast cancer cell line
Negative control: H1299 lung carcinoma cell line
Immunohistochemistry Recommended dilution: 1 µg/ml
Positive tissue: breast cancer
Immunohistochemistry (frozen sections) Recommended dilution: 1 µg/ml
Positive tissue: breast cancer
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Endoplasmic reticulum |
| Tissue Specificity: | Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690). |
| BioGrid: | 127586. 17 interactions. |
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