Anti-ABRA1 Monoclonal Antibody (Clone:ABRA1-01)
Figure 1: Detection of ABRA1-EGFP fusion protein in lysate of transfected HEK293 cells. Lane A: Immunostaining with anti-ABRA1 (clone ABRA1-01). Lane B: Immunostaining with anti-EGFP (polyclonal). Lane C: Immunostaining with anti-alpha tubulin (clone TU-01)
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG |
| Purification : | Purified by protein-A affinity chromatography |
| Content : | 1 mg/ml; Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage condition : | Store at 2-8°C. Do not freeze. |
ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
| Subcellular location: | Nucleus |
| Post transnational modification: | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1 (PubMed:17643121, PubMed:17525340, PubMed:17643122). Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM; this promotes recruitment of BRCA1 to sites of DNA damage (PubMed:26778126). |
| BioGrid: | 123911. 20 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
