Animal-Free Recombinant Murine IL-4(Discontinued)

Product code: 32-20339

Reactivity : Mouse, Rat

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For estimated delivery dates, please contact us at [email protected]


Amount : 20 µg
Purification : Purity: >= 98% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Alternative Name : BCGF, BCDF, B cell stimulating factor (BSF-1)
Source:E.coli
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is <= 2.0 ng/ml, corresponding to a specific activity of >= 5 x 105 units/mg

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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